gammaCore activates your vagus nerve with a safe and gentle patented electrical stimulation that travels through your skin.1,2 Once activated by gammaCore, your vagus nerve then acts to block the signals that are causing your episodic cluster headache pain.1,3 Another form of vagus nerve stimulation has been used safely for more than 20 years to treat a number of conditions.4
The vagus nerve—the longest nerve of the head—has been called the “great wandering protector.”5 It extends throughout much of your body and serves as a control center to regulate many body systems.5,6 The vagus nerve plays a role in regulating pain, inflammation, and mood.1,5
- Silberstein SD, Mechtler LL, Kudrow DB, et al; ACT1 Study Group. Non-invasive vagus nerve stimulation for the acute treatment of cluster headache: findings from the randomized, double-blind, sham-controlled ACT1 study. Headache. 2016;56(8):1317-1332.
- gammaCore Instructions for Use. Basking Ridge, NJ: electroCore; 2017.
- Nesbitt AD, Marin JC, Tompkins E, Ruttledge MH, Goadsby PJ. Initial use of a novel noninvasive vagus nerve stimulator for cluster headache treatment. Neurology. 2015;84(12):1249-1253.
- Yuan H, Silberstein SD. Vagus nerve and vagus nerve stimulation, a comprehensive review: part II. Headache. 2016;56(2):259-266.
- Yuan H, Silberstein SD. Vagus nerve and vagus nerve stimulation, a comprehensive review: part I. Headache. 2016;56(1):71-78.
- Patestas MA, Gartner LP. Cranial nerves. In: Patestas MA, Gartner LP, eds. A Textbook of Neuroanatomy. 2nd ed. Hoboken, NJ: John Wiley & Sons; 2016:315-349.